Journal of Medicinal and Chemical Sciences

Clinical Features of Course of Different Types of Carpal Tunnel Syndrome

Oksana Haiko; Liudmyla Klymchuk; Roman Derkach; Valentyn Piontkovskyi

Volume 6, Issue 10 , October 2023, , Pages 2494-2501

https://doi.org/10.26655/JMCHEMSCI.2023.10.23

Abstract

Objective: This article aims to study clinical features of the courses of different types of CTS to improve diagnostics and substantiate tactics of treatment.Materials and methods: ... Read More

Detection of Active Chemical Compounds in Lycium Shawii Plant Using GC-MS Technique and Their Evaluation as Antioxidant

Ebtihaj Jassim Jabur; Ali Noory Fajer

Volume 6, Issue 10 , October 2023, , Pages 2518-2530

https://doi.org/10.26655/JMCHEMSCI.2023.10.26

Abstract

Lycium shawii is considered a thorny perennial and wild plant. Bramble usually grows in dry and hot lands because this plant lives on moisture. The height of the plant reaches one and ... Read More

Effect of Androgen Use among Children with Micropenis in Erbil City

Wesam Amjad Boya Kaka

Volume 6, Issue 10 , October 2023, , Pages 2531-2538

https://doi.org/10.26655/JMCHEMSCI.2023.10.27

Abstract

Background and objective: Micropenis is a condition where the penis is smaller than average, causing psychological distress and affecting sexual function. The aim of this study was ... Read More

Nurse Performance and Influence Factors in Discharge Planning Based on Knowledge Management SECI Model in Stroke Patients

Auliasari Siskaningrum; Ahmad Yusuf; Mahmudah Mahmudah; Abdulloh Machin

Volume 6, Issue 10 , October 2023, , Pages 2558-2568

https://doi.org/10.26655/JMCHEMSCI.2023.10.30

Abstract

Background: Implementation of discharge planning was found to be unsystematic and structured in stroke patients, resulting in gaps in knowledge transfer and knowledge between nurses, ... Read More

Density Functional Theory, ADME, and Molecular Docking of Some Anthranilic Acid Derivatives as Cyclooxygenase Inhibitors

Karam S. Atrushi; Dana M. Ameen; Shaymaa H. Abdulrahman; Faris T. Abachi

Volume 6, Issue 9 , September 2023, , Pages 1943-1952

https://doi.org/10.26655/JMCHEMSCI.2023.9.3

Abstract

Nonsteroidal anti-inflammatories (NSAIDs), are very effective agents in relieving mild to moderate pain and inflammation by inhibiting two isoforms of prostaglandin G-H synthetase (I ... Read More

Predictors of Mortality in Sepsis Patients Resulting from Severe and Critical COVID-19

Nur Farhanah; Supriadi Supriadi; Hendro Wahjono; Suharyo Hadisaputro; Muhammad Hussein Gasem

Volume 6, Issue 9 , September 2023, , Pages 2018-2027

https://doi.org/10.26655/JMCHEMSCI.2023.9.10

Abstract

Patients with severe and critical COVID-19 may exhibit sepsis and mortality resulting from multi-organ failure. Neutrophil-lymphocyte-ratio (NLR) values, C-reactive protein (CRP) levels, ... Read More

Survival Analysis of Delta versus Omicron Variants in COVID-19 Intensive Care Unit (ICU)

Somayeh Mehrpour; Mojdeh Bahadorzadeh; Hassan Safdari; Mansoureh Shakeri; Reihane Tabaraii

Volume 6, Issue 9 , September 2023, , Pages 2038-2045

https://doi.org/10.26655/JMCHEMSCI.2023.9.12

Abstract

Objective: COVID-19 has presented numerous epidemiological and clinical pictures from its beginning and much effort has been paid to detect the behavior of disease and its new types. ... Read More Objective: COVID-19 has presented numerous epidemiological and clinical pictures from its beginning and much effort has been paid to detect the behavior of disease and its new types. Therefore, in this study, we aimed to compare the in-hospital survival time of Delta and Omicron variant patients admitted to the intensive care unit. Methods: This was a secondary data analysis of the QCOVICU data registry of 200 COVID-19 patients admitted to the ICU of Shahid Beheshti-Amir Al-Momenin Hospital of Qom City, in 2021. Likewise, time to event data, demographics, and baseline laboratory data was collected. Time of transfer to ICU, survivals, and possible predictors of hazards of death was compared within the variants of Omicron and delta.Results: Two hundred patients (62.98±19.94 years old, 94 females/106 males; 100 Delta and 100 Omicron variant) participated in this study. Fifty percent of the population had died. Cross-tabulation showed comparable death rates among variants of delta and omicron (50.5% vs. 51%; p=0.999). There was a statistically significant higher time to ICU admission in Delta variant victims than in Omicron variant victims. The mean survival time of delta variant patients was 21.52 days (95% CI: 17.96 – 25.09) which was statistically higher than the mean survival of omicron patients (17.15 days, 95% CI: 13.65-20.64, p=0.018). The mean survival time of delta variant patients was ‎statistically higher than omicron patients (21.52 vs. 17.15 days, ‎p=0.018). Gender, age (years), and lymphocyte count were significant predictors of mortality based on the Cox regression analysis (P>0.05). There was a 5.9 times higher risk of mortality in females compared with males’ gender after adjusting for other variables and a 5.6% increase in death risk with a 1-year increase in age, and a 31.8% decrease in death risk with a 1% lymphocyte percentage increase.Conclusion: Critically patients with Delta variant are getting ICU admitted later and withstand more days at ICU than Omicron patients. It seems that Omicron variant causes sudden deterioration of the patient's condition.

Modified Lung Ultrasound Score to Determine the Degree of Perioperative Atelectasis in Adults Undergoing Elective Laparoscopic Surgery Under General Anaesthesia- A Prospective Observational Study

Dhivya R; Arun Prasath D; Yachendra V.S.G; Surya R; Lakshmi Ramakrishnan

Volume 6, Issue 9 , September 2023, , Pages 2104-2110

https://doi.org/10.26655/JMCHEMSCI.2023.9.17

Abstract

Background: Lung ultrasound score (LUS) is a semiquantitative assessment tool that has been proposed to assess lung aeration changes in mechanically ventilated patients after therapeutic ... Read More

The Role of Dynamic (99m) Tc Pertechnetate Scintigraphy in Early Detection and Differentiation of Hyperthyroidism

Ramë Miftari; Hana Maloku; Afërdita Bajqinca; Bujar Rexhaj; Sanije Miftari; Ylli Kaqiu

Volume 6, Issue 9 , September 2023, , Pages 2177-2185

https://doi.org/10.26655/JMCHEMSCI.2023.9.23

Abstract

Thyrotoxicosis is hypermetabolic states that is not always associated with hyperfunction of thyroid gland and can present a problem in diagnostic differentiation. We have tried to prove ... Read More

Upregulation of INSR Gene Expression and Restoration of Melatonin Levels by Tinospora Cordifolia Stem Extract and Alkaloid Rich Fraction against Continuous Light Induced Polycystic Ovary Syndrome in Rodents

Murali Krishna Moka; Sumithra M

Volume 6, Issue 9 , September 2023, , Pages 2198-2217

https://doi.org/10.26655/JMCHEMSCI.20239.25

Abstract

Females of childbearing age often suffer from polycystic ovary syndrome (PCOS), a hormonal condition. Symptoms including insulin resistance, high androgen levels, irregular menstrual ... Read More Females of childbearing age often suffer from polycystic ovary syndrome (PCOS), a hormonal condition. Symptoms including insulin resistance, high androgen levels, irregular menstrual (estrous) cycles, and polycystic ovaries are linked to this condition. The study's objective is to determine the therapeutic effect of Tinospora cordifolia stemextract and Alkaloid Rich Fraction against continuously Light Induced Polycystic Ovary Syndrome in Sprague Dawley (SD) female rats. Animals were grouped into six groups where the control group received only distilled water and the standard group received Clomiphene citrate 20 mg/Kg. The test groups received Tinospora cordifolia Stem Extract (200 mg/kg b.w and 400 mg/kg b.w) and Alkaloid Rich Fraction (10 mg/kg b.w and 20 mg/kg b.w) for the period of 4 weeks after PCOS induction. The results showed a significant reduction in elevated testosterone levels compared to that of the PCOS group (Light Induced Group (L/L 24 hrs Continuous), but follicle-stimulating hormone (FSH), insulin levels reported significant increase compared to that of the L/L PCOS group (Light Induced Group (L/L 24 hrs Continuous) and increased expression of INSR gene and restoration of melatonin levels. From the results, it was concluded that High doses of Tinospora cordifolia Stem Extract (400 mg/kg b.w) and Alkaloid Rich Fraction (20 mg/kg b.w) could be effective against Continuously Light Induced Polycystic Ovary Syndrome in Rodents it has due to decreased testosterone levels and increase insulin sensitivity by up-regulating INSR gene expression followed by restoration of melatonin levels. After treatment period a significant decrease in elevated LH levels, testosterone levels, and a significant increase in insulin and follicle-stimulating hormone (FSH) levels when compared to the L/L PCOS group (Light Induced Group (L/L 24 hrs Continuous), as well as increased INSR gene expression and restored melatonin levels.

Tofacitinib in Pharmaceutical Solid Dosage from Dissolution Study: Development and Validation of RP-HPLC Method

Krishna Prasad Narapereddy; Devi Sravanthi Alladi

Volume 6, Issue 9 , September 2023, , Pages 2218-2227

https://doi.org/10.26655/JMCHEMSCI.2023.9.26

Abstract

A simple, sensitive, precise, and accurate reversed phase high performance liquid chromatographic (RP-HPLC) method has been developed for the dissolution study of Tofacitinib in Tofacitinib ... Read More

Evaluation of Relationship between Serum Hemoglobin A1C Level and Severity of Diabetic Foot Ulcers Based on Wagner Criteria

Alireza Ghanbari; Majid Nouri; Mohammad Darvishi

Volume 6, Issue 9 , September 2023, , Pages 2234-2241

https://doi.org/10.26655/JMCHEMSCI.2023.9.28

Abstract

Introduction: One of the important risk factors for diabetic patients, including foot ulcers, is lack of blood sugar control, the standard criterion for which in the long run is the ... Read More

Type-2 Diabetes Among Investors Community in India

Srutiva Mishra; B. Chandra Mohan Mohan Patnaik; Ipseeta Satpathy

Volume 6, Issue 9 , September 2023, , Pages 2249-2258

https://doi.org/10.26655/JMCHEMSCI.2023.9.30

Abstract

Comorbidity and mortality are high among people with type-2 diabetes. Globally, diabetes is a major health issue, with a growing number of patients at risk of complications. A change ... Read More

Safety and Efficacy of Popular Iranian Herbal Cold Remedy for COVID-19: A Randomized Clinical Trial in Mild to Moderate COVID-19 Cases

Samaneh Abiri; Alireza Hashemi Shiri; Mohammad Sadegh Sanie Jahromi; Esmaeil Rayatdoost; Hamid Afkhami; Ruhollah Ravanshad; Seyed Ehsan Hosseini; Navid Kalani; Parasta Heidari; Rahim Raoufi

Volume 6, Issue 8 , August 2023, , Pages 1799-1809

https://doi.org/10.26655/JMCHEMSCI.2023.8.8

Abstract

Background: In traditional Persian medicine, an herbal cold remedy containing Sugarcane, Black Myrobalan, and mastic is mentioned and it was being widely provided by grocery stores. ... Read More Background: In traditional Persian medicine, an herbal cold remedy containing Sugarcane, Black Myrobalan, and mastic is mentioned and it was being widely provided by grocery stores. With the advent of the COVID-19 pandemic, the increased desire for this traditional remedy has led to a debate in society. Huge parts of the Iranian population have started using this remedy for the treatment of COVID-19; while no study has evaluated its efficiency and possible side effects. Thus, we aimed to evaluate the effects of Sugarcane, Black Myrobalan, and Mastic‏ ‏herbal medications for COVID-19 patients.Methods: This was a double-blinded randomized clinical trial study conducted over three months from May 2020 to July 2020 in SARS-COV2 PCR positive patients admitted in the COVID-19 ward of Peymaniyeh Hospital in Jahrom, Iran. Patients with severe COVID-19 infection were not recruited. The intervention group received the routine COVID-19 treatment protocol and the herbal supplement received the combination of black myrobalan and mastic and sugarcane, twice a day (3 g of herbal supplement). Study groups were compared in terms of demographic variables, vital signs, and clinical and laboratory variables for safety and efficiency assessment.Results: Seventy-two patients with COVID-19, divided into intervention (n=37) and control (n = 35) groups were studied. Intervention and control groups had not any significant difference in terms of baseline characteristics. The time-to-event analysis revealed a statistically significant difference in 4 symptoms of cough, fever, dyspnea, and myalgia (P<0.05). There was no significant difference in averaged O2 vital signs between the two groups (P>0.05). The Control group in comparison to the intervention group had a significantly lower decrease in C-reactive protein during 7 days (P<0.05). Patients in the herbal supplement group were hospitalized for 4.12 days and patients in the control group were hospitalized for 8.37 days (P=0.001). ICU admission and death only happened in 3 (8.6%) patients of the control group.Conclusion: This study showed that the proposed herbal remedy could be applied as supplementation to conventional management of COVID-19 patients with mild disease, while more research is needed for clinical application of this remedy.

Synthesis of Dihydropyrimidinone (DHPM) Derivatives through a Multicomponent Reaction (MCR) and Their Biological Activity

Ahmad Fauzi; Azis Saifudin; Kamal Rullah

Volume 6, Issue 8 , August 2023, , Pages 1810-1817

https://doi.org/10.26655/JMCHEMSCI.2023.8.9

Abstract

The spread of incurable diseases, especially infectious diseases caused by antibiotic-resistant bacteria and certain cancers, has become a serious public health concern. Consequently, ... Read More

Potential Role of Selenium to Ameliorate Doxorubicin Induced Cardiotoxicity in Male Rats

Rusul Nadheer Albakaa; Fadhil A. Rizij; Rafid M. Ali Hassan

Volume 6, Issue 7 , July 2023, , Pages 1498-1505

https://doi.org/10.26655/JMCHEMSCI.2023.7.3

Abstract

Abstract: Selenium (SE) is well known for its immune boosting, antioxidant, and anti-tumor properties. Doxorubicin (DOXO), a commonly used chemotherapy drug, causes cardiac-damage by ... Read More Abstract: Selenium (SE) is well known for its immune boosting, antioxidant, and anti-tumor properties. Doxorubicin (DOXO), a commonly used chemotherapy drug, causes cardiac-damage by increasing the level of reactive oxygen species (ROS). Selenium (SE) is well known for its immune boosting, antioxidant, and anti-tumor properties. Doxorubicin (DOXO), a commonly used chemotherapy drug, causes cardiac-damage by increasing the level of reactive oxygen species (ROS). SE has been shown to improve heart development dysregulation, CMY structural damage, antioxidant enzyme (GSH, and SOD) activity, and caspase-3 (CASP3) levels in the cardiac tissue. Furthermore, SE could reduce the inflammation marker, ICAM-1 activity, and cardiotoxicity marker levels in the serum, cTn-1 serum levels. Finally, SE may protect against cardiotoxicity by inhibiting the oxidative induced by doxorubicin.Objectives: The aim of the study is to investigate if selenium has protective role against the cardiotoxicity induced by DOXO in laboratory rats.Method: A total of 32 male rats were used, and they were randomly divided into 4-groups (8 rats * in each group). The rats in the control group started drinking distilled water for the experiment period. Rats in the doxorubicin group (the induced group) were given 2.5 MG/KG three times per wek, continue for 2-weeks. The second group was treated with SE only had SE administered at a dose of 1 mg/kg, continue for 2-weeks. Results: Doxorubicin induced cardiotoxicity, as shown by a significant increase (~P < 0.001) in the levels of cTnI, ICAM-1, and caspase-3. At the same time, the levels of GSH and SOD when compared to the control group, were significantly reduced (P < 0.001) in the cardiac tissues of rats in the doxorubicin treated group. Histological changes and lesions were also caused by the Doxo. The administration of selenium was found to reduce cardiotoxicity, this can be proved by significant-decreases (p* < 0.001) in cardiac-TnI, ICAM-1, casp-3 and significant-increases (~P < 0.001) in SOD and GSH when compared to the DOXO group; and significant improvements (~P < 0.001) in the score for cardiomyopathy histopathological lesions.Conclusion: At the drugs-doses used in this study, selenium protected the hearts of rats from DOXO-induced cardiotoxicity. This is may related to the interfered and may ameloirate oxidative stress, inflammation, and the apoptotic pathway.

Cancer in Maysan: Mortality, Pattern, and Demographic Characteristics during the Last 4 Decades

Sadiq Musa Ahmed; Hmood Madhi Hasan

Volume 6, Issue 7 , July 2023, , Pages 1548-1554

https://doi.org/10.26655/JMCHEMSCI.2023.7.7

Abstract

Cancer is considered as one of the serious diseases recognized by the abnormal cells division which can be invading normal cells and tissues. People can be affected by cancer at any ... Read More

Impact of RAGE Gene rs80096349(C>T), rs1035798(C>T), and rs184003(G>T) Polymorphisms on Non-Response to Aspirin in Iraqi Patients with Coronary Artery Disease

Faleh A Khudhair; Shatha H Ali; Khalil A Al-Zubeidi

Volume 6, Issue 7 , July 2023, , Pages 1582-1597

https://doi.org/10.26655/JMCHEMSCI.2023.7.10

Abstract

Background: Transmembrane multiligand receptor RAGE is a protein found on the surface of cells that binds to the advanced glycation end products. Platelet cyclooxygenase activity is ... Read More Background: Transmembrane multiligand receptor RAGE is a protein found on the surface of cells that binds to the advanced glycation end products. Platelet cyclooxygenase activity is elevated in response to RAGE activation, contributing to the formation of a thrombus.Objectives: To examine the connection between RAGE gene rs80096349(C>T), rs1035798(C>T), and rs184003(G>T) polymorphisms and resistance to aspirin in CAD patients from Iraq.Patients and methods: Patients with coronary artery disease (CAD) (161 males and 64 females) were enrolled in the trial between February 2021 and October 2021. All participants were taking prophylactic Aspirin (100 mg). The control group consisted of 130 individuals, including 97 males and 33 females, who appeared to be in good health and were not taking aspirin. Serum thromboxane B2 levels were used to assess the effectiveness of aspirin (TBX2). Patients were classified as either aspirin sensitive or resistant. The polymorphism of RAGE's most closely related single nucleotide polymorphisms (SNPs) was identified using polymerase chain reaction for amplification of the extracted deoxyribonucleic acid and Sanger's method of sequencing.Results: A total of 225 cardiovascular patients compatible with inclusion criteria were enrolled. There were 161(71.6%) male and 64(28.4%) female patients with a mean age of 56.85±8.11years old. The statistical analysis revealed 17.8% (n = 40) aspirin-resistant cases in the study population. Genotypic analysis of our data showed that participants with the T allele of rs184003(G/T) had an increased prevalence in the aspirin-resistant group compared with the aspirin-sensitive group (p<0.05). In contrast, for rs10835798, the frequency was dramatically higher for T alleles in aspirin sensitive group contrasted with the resistant group (p<0.05). The aspirin-resistant group was found to have significantly greater RAGE levels than the sensitive group.Conclusion: Our results provide evidence that RAGE expression and gene rs1035798(C>T), and rs184003(G>T) polymorphisms could be predictors for CAD patients' resistance to aspirin.

The Placebo and Laughter Therapy Efficacy on Pain Perception, Sleep Quality, and Post-traumatic Growth in Recovering Drug Abusers

Seyed Amir Omrani

Volume 6, Issue 7 , July 2023, , Pages 1631-1645

https://doi.org/10.26655/JMCHEMSCI.2023.7.14

Abstract

This research was designed to study the efficacy of placebo and laughter therapy on pain perception, sleep quality, and post-traumatic growth in recovering drug abusers. Thus, among ... Read More This research was designed to study the efficacy of placebo and laughter therapy on pain perception, sleep quality, and post-traumatic growth in recovering drug abusers. Thus, among 1050 patients who had been referred to the Empowerment and Protection Center for Recovered of the Hamrahan Aftab of Sari City in Iran during the last 5 years (2016-2021) 60 recovered were randomly selected. This study was conducted with a quantitative structure in the form of an experimental design with pre-test-post-test and control in three experimental and control groups. Thus, 4 independent groups were selected by simple random assignment and each of them was exposed to placebo, laughter therapy, combination therapy, and neutral approaches (control group), respectively. Findings were presented in two descriptive and analytical sections: the descriptive section addressed the status of each variable in the statistical sample and in the analytical section, the relationship between the independent variables with each of the three dependent variables of the research, including pain perception, sleep quality, and post-traumatic growth, was measured. The statistical tests included univariate regression (to measure the simple relationship between independent and dependent variables) and T-test (comparing the effectiveness of variables). Findings demonstrated that each of the studied factors, placebo and laughter therapy, had an effect on all dependent variables of pain perception, sleep quality, and post-traumatic growth so that both of these factors (independently) reduce pain perception, increase sleep quality, and increase growth after injury. However, the T-test demonstrated that in all groups the effect of laughter therapy was higher than placebo (that is, laughter therapy has been able to reduce pain perception and increase sleep quality and post-injury growth in drug abuse recoveries more than placebo), which can pave the way for drug addiction treatment, life recovery afterward, and complete recovery: Laughter therapy is formed easier than placebo, has lower costs, and higher efficiency. Conclusively, findings were similar in the follow-up period (quarterly).

Effect of Phytosterols on Brain Development in Iodine Deficient Rat Model- A Comparative Study

Rashmi Chandra; Chaiti Ganguly

Volume 6, Issue 7 , July 2023, , Pages 1696-1705

https://doi.org/10.26655/JMCHEMSCI.2023.7.19

Abstract

Iodine deficiency leads to insufficient production of thyroid hormone which may cause many harmful consequences in humans. Owing to the cumulative impact of maternal, prenatal, and ... Read More

Knowledge and Awareness of the Side Effects and Drug Interactions of Antibiotics and Analgesics Among the Dental Students in Iraq

Hanadi Hadi Jasim Al-Khafaji; Mohammed Faris Jubaz; Asseel Mohammed Ghazi

Volume 6, Issue 6 , June 2023, , Pages 1265-1275

https://doi.org/10.26655/JMCHEMSCI.2023.6.7

Abstract

AbstractBackground and Aim: Students in dentistry colleges in Iraq can prescribe some medications during the fourth and fifth year of their undergraduate study of dentistry under the ... Read More

Molecular Identification of Virulence Genes Salmonella Enterica Isolated of Animal and Human Diarrheal

Semaa Hassen Shalal; Nawres Norri Jaber; Khwam Reissan Hussein

Volume 6, Issue 6 , June 2023, , Pages 1302-1309

https://doi.org/10.26655/JMCHEMSCI.2023.6.10

Abstract

Salmonella enterica is the leading cause of food poisoning in some countries. Salmonella species are the most prevalent causes of foodborne illness in humans and animals. S. enterica ... Read More

Assessment of Anti-Diabetic and Antioxidant Activities of Rourea Minor Stems in Streptozotocin-Induced Diabetic Rats

Kavya Yedelli; Ramachandran Kumar Pathangi

Volume 6, Issue 6 , June 2023, , Pages 1370-1382

https://doi.org/10.26655/JMCHEMSCI.2023.6.17

Abstract

Rourea minor is a medicinal plant with anti-diabetic properties, and it can be found in South and North Asian countries. The study design involves the preparation of an ethanol Rourea ... Read More

Transurethral Resection of Prostate (TURP) Against Transurethral Incision of Prostate (TUIP) in Benign Prostatic Hyperplasia Management

Rafid Fakher Hussein Al Husseini; Ahmed Turki Obaid; Ahmed Hamid Abdulhasan Al Aridhee

Volume 6, Issue 6 , June 2023, , Pages 1426-1432

https://doi.org/10.26655/JMCHEMSCI.2023.6.22

Abstract

As men age, a condition known as benign prostatic hyperplasia (BPH), or enlargement of the prostate gland, becomes more prevalent. The technique of transurethral incision of the prostate ... Read More

Levosimendan Versus Dobutamine in Children with Acute Heart Failure

Mohanad K. Shukur Al-Ghanimi; Khalid A. Khalid

Volume 6, Issue 6 , June 2023, , Pages 1433-1443

https://doi.org/10.26655/JMCHEMSCI.2023.6.23

Abstract

Heart failure in children causes substantial morbidity and mortality, so we need an inotropic agent like levosimendan that improves the hemodynamics and relief of symptoms without adverse ... Read More

Volume 7 (2024)

Volume 6 (2023)

Volume 5 (2022)

Volume 4 (2021)

Volume 3 (2020)

Volume 2 (2019)

Volume 1 (2018)

Main Subjects = Pharmaceutical sciences

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